Author's Response to Reviews: See Over

1)Methods section did not have enough detailed information about the recruitment of patients and the examinations Response: Thanks for the reviewer’s kind suggestion.According to his/her advices, the manuscript has been modified,page 2, Methods section 2) Is the conclusion really reflecting the actual conclusion of the study? Response: Thanks for the reviewer’s suggestion.The manuscript has been modified,page 3, conclusion section Introduction: 3) There are referencing errors such as: o “ Infectious keratitis is still one of the main causes of ocular damage and visual disability” none of the references sited for this phrase is an actual prevalence Study. Response: Thanks for the reviewer’s kind suggestion.According to his/her advices,The manuscript has been modified" Infectious keratitis is still one of the main causes of corneal blindness and visual Disability" Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79:214–221. o Based on the WHO, other main causes of visual impairment in 2002 are glaucoma (12.3%), age-related macular degeneration (AMD) (8.7%) and then corneal opacities (5.1%) Response:Thanks for the reviewer’s kind suggestion. The manuscript was revised, I have rewrite “Infectious keratitis is still one of the main causes of ocular damage and visual disability”to “Infectious keratitis is still one of the main causes of corneal blindness and visual Disability”, Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79:214–221. 4) There are phrases which need references such as : o Through the perseverance of public health programs, the morbidity of corneal diseases due to Chlamydia trachomatis, Onchocerciasis, and leprosy have been controlled relatively stable. Response:Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bull World Health Organ. 2001;79:214–221. o China is estimated to have the largest number of blind people globally Response:Global Initiative For The Elimination Of Avoidable Blindness. Available at: http://www.who.int/inf-fs/en/fact230.html. 1999 o Is the China’s First National Sample Survey of Disabled Persons really suggested infectious keratitis as a major cause of corneal blindness? Response:Thanks for the reviewer’s kind suggestion.The text had already been marked up with corrections marked in red in the paper , page 5, line 11. I have rewrite “China’s First National Sample Survey of Disabled Persons suggested that infectious keratitis was a major cause of corneal blindness, accounting for approximately one-fourth of the cases of blindness in China.”to”China’s First National Sample Survey of Disabled Persons suggested that corneal disease as a major cause of blindness and low vision ranks second only to cataract in china, and the prevalence of corneal blindness and low vision was 11.5/10000, accounting for approximately one-sixth of the cases of blindness in China.” 5) Although some demographic characteristics of the patients are evaluated in this study, the risk factors of infectious keratitis were not evaluated in this study like it says in the objective Response: Thanks for the reviewer’s kind suggestion. table 4 "Univariate analysis of the prevalence of infectious corneal diseases" indicate that infectious keratitis presented in higher prevalence in the patients who live in rural areas and those receiving less education, and the prevalence increased with age. According to the reviewer’s advices, we discussed if the gender constitutes a risk factor, and devoted a lengthy and full discussion to this topic access to raw data, we believe that the gender is not the ultimate risk factors for Infectious keratitis in central China, And the proper interpretation and analysis of the result was carried out in the result and discuss section marked in red in the paper.